Ferreras-Estrada M C, García-Iglesias M J, Pérez-Martínez C, Manga-González M Y, Ramajo-Martín V, Escudero-Diez A, García-Marín J F
Departamento de Patología Animal, Medicina Animal, Facultad de Veterinaria, Universidad de León, Spain.
J Comp Pathol. 1998 Nov;119(4):479-84. doi: 10.1016/s0021-9975(98)80042-x.
The pathological response of sheep to two dose levels (400 or 10,000 cercariae) of Schistosoma bovis was evaluated 24 weeks after infection. The results confirmed that a single low or high dose causes lesions in the liver and intestine, and that the lungs, lymph nodes, pancreas and abomasum are affected in sheep given a single high dose. In addition, the study showed that pathological changes (mainly a granulomatous inflammatory reaction) were induced not only by eggs but also by adult worms, and that their severity was in general related to the dose of S. bovis. Hoeppli reaction product, observed on the surface of adult schistosomes in some parasitic granulomas, showed no immunoreaction for IgG, IgA or IgM.
在感染后24周评估了绵羊对两种剂量水平（400或10000尾尾蚴）牛血吸虫的病理反应。结果证实，单次低剂量或高剂量都会导致肝脏和肠道出现病变，并且在给予单次高剂量的绵羊中，肺、淋巴结、胰腺和皱胃也会受到影响。此外，该研究表明，不仅虫卵，成虫也会引发病理变化（主要是肉芽肿性炎症反应），并且其严重程度通常与牛血吸虫的剂量有关。在一些寄生性肉芽肿中，在成虫血吸虫表面观察到的赫氏反应产物对IgG、IgA或IgM无免疫反应。
