Schwartz P J, Stone H L, Brown A M
Am Heart J. 1976 Nov;92(5):589-99. doi: 10.1016/s0002-8703(76)80078-6.
In anesthetized dogs the circumflex and/or the anterior descending coronary artery were briefly occluded (10 to 90 seconds) and ectopic beats occurring during the occlusion or for 60 seconds following release were counted. Control occlusions were alternated with occlusions performed during complete, reversible, unilateral blockade of either the right or the left stellate ganglion. This was achieved with thermodes through which coolant was circulated. In this way the shortcomings associated with stellectomy, which is irreversible, are avoided. Blockade of the right stellate ganglion increased the number of ectopic beats associated with coronary occlusion. The occurrence of episodes of ventricular tachycardia and fibrillation was also greater. By contrast, blockade of the left stellate ganglion reduced or abolished occlusion-induced arrhythmias. These effects are independent of changes in heart rate or vegal activity; they depend solely upon unilateral alteration in sympathetic tone, and are not demonstrable when such tone is low. We suggest that the right and left cardiac sympathetic nerves have a different influence upon cardiac excitability.
在麻醉犬中，左旋支和/或前降支冠状动脉被短暂阻断（10至90秒），并计算阻断期间或解除阻断后60秒内出现的异位搏动。对照性阻断与在右侧或左侧星状神经节完全、可逆、单侧阻断期间进行的阻断交替进行。这是通过循环冷却液的热电极实现的。通过这种方式，避免了与不可逆的星状神经节切除术相关的缺点。右侧星状神经节的阻断增加了与冠状动脉阻断相关的异位搏动数量。室性心动过速和颤动发作的发生率也更高。相比之下，左侧星状神经节的阻断减少或消除了阻断诱导的心律失常。这些效应与心率或迷走神经活动的变化无关；它们仅取决于交感神经张力的单侧改变，当这种张力较低时则无法显示。我们认为，右侧和左侧心脏交感神经对心脏兴奋性有不同的影响。
