Dyer J R, Edis R H, French M A
Department of Clinical Immunology, Royal Perth Hospital, Western Australia, Australia.
J Neurovirol. 1998 Oct;4(5):569-71. doi: 10.3109/13550289809113502.
We report a case of relapsing multifocal neurological disease associated with CNS echovirus 6 infection in an HIV-1-infected individual with no evidence of immunoglobulin deficiency. The illness was initially characterized by optic and cranial neuropathies and myelopathy; concurrent granulomatous hepatitis suggested disseminated viral infection. Treatment with combination nucleoside analogues led to partial remission, but a demyelinating polyneuropathy subsequently developed. There was improvement and sustained remission in the polyneuropathy following treatment with intravenous immunoglobulin. Neurotropic enterovirus infection may be involved in the pathogenesis of certain HIV-associated neurological syndromes.
我们报告了一例在未发现免疫球蛋白缺乏证据的HIV-1感染个体中，与中枢神经系统埃可病毒6感染相关的复发性多灶性神经疾病病例。该疾病最初表现为视神经和颅神经病变以及脊髓病；同时出现的肉芽肿性肝炎提示病毒播散性感染。联合核苷类似物治疗导致部分缓解，但随后出现了脱髓鞘性多发性神经病。静脉注射免疫球蛋白治疗后，多发性神经病有所改善并持续缓解。嗜神经性肠道病毒感染可能参与了某些HIV相关神经综合征的发病机制。
