Petrus D J, Jackson M W, Kemnitz J W, Finegood D T, Panciera D
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA.
Res Vet Sci. 1998 Sep-Oct;65(2):179-81. doi: 10.1016/s0034-5288(98)90174-6.
Current methods of assessing glucose tolerance in the cat are inadequate for quantifying insulin sensitivity. The hyperinsulinemic euglycemic clamp (EGC) and the minimal model analysis (MMA) of the frequently sampled intravenous glucose tolerance test (FSIGT) have been used in other species to assess the effects of insulin on glucose homeostasis. Each of these procedures was performed on healthy cats, two weeks apart, to generate indices of insulin sensitivity - M/I (amount of glucose metabolised per unit of plasma insulin concentration) from the EGC and S(I) (insulin sensitivity) from the MMA. Close and significant correlation between M/I and S(I) in individual cats was found (r=0.91, P=0.032). Use of these research methods may further our understanding of feline diabetes mellitus and other endocrinopathies.
目前评估猫葡萄糖耐量的方法不足以量化胰岛素敏感性。高胰岛素正常血糖钳夹技术（EGC）和频繁采样静脉葡萄糖耐量试验（FSIGT）的最小模型分析（MMA）已被用于其他物种，以评估胰岛素对葡萄糖稳态的影响。对健康猫每隔两周进行一次这些操作，以生成胰岛素敏感性指数——来自EGC的M/I（每单位血浆胰岛素浓度代谢的葡萄糖量）和来自MMA的S(I)（胰岛素敏感性）。发现个体猫的M/I和S(I)之间存在密切且显著的相关性（r=0.91，P=0.032）。使用这些研究方法可能会加深我们对猫糖尿病和其他内分泌疾病的理解。
