Hattersley P G
Am J Clin Pathol. 1976 Nov;66(5):899-904. doi: 10.1093/ajcp/66.5.899.
The activated coagulation time of whole blood (ACT) has, in the nearly ten years since its first description in the literature, proven itself one of the best laboratory tests for the control of heparin therapy, both for patients undergoing treatment for thromboembolic disease and for those on extracorporeal circulation. It is simple, largely free from subjective variation, precise, and quick. Prolongation of the ACT in the heparinized individual is directly proportional to the concentration of heparin in the blood, and the test accurately reflects the semilogarithmic disappearance of the anticoagulant effect in most patients. In addition, the test serves well as a bedside screening test for deficiencies of the intrinsic coagulation mechanism. The author summarizes the sutdies that have been carried out on this technic since its original description, and briefly presents three protocols for heparinization of patients who have thromboembolic disease.
全血活化凝血时间（ACT）自首次在文献中描述以来的近十年间，已证明自身是控制肝素治疗的最佳实验室检测方法之一，适用于接受血栓栓塞性疾病治疗的患者以及进行体外循环的患者。它操作简单，基本不受主观因素影响，精确且快速。肝素化个体的ACT延长与血液中肝素浓度成正比，该检测能准确反映大多数患者抗凝效果的半对数消失情况。此外，该检测作为内源性凝血机制缺陷的床旁筛查检测也表现良好。作者总结了自该技术首次描述以来所进行的研究，并简要介绍了三种针对血栓栓塞性疾病患者的肝素化方案。
