Kajiyama Y, Tsurumaru M, Udagawa H, Tsutsumi K, Kinoshita Y, Ueno M, Akiyama H
Department of Surgery, Toranomon Hospital, Tokyo, Japan.
Hepatogastroenterology. 1998 Sep-Oct;45(23):1442-5.
BACKGROUND/AIMS: In the chemotherapy of recurrent gastric cancer with 5-fluorouracil and folinic acid, an interesting phenomenon, the reduction of jaundice and improvement of liver function, was observed. The aim of this study was to investigate the mechanism of this phenomenon, and to confirm a choleretic effect of folinic acid.
The bile duct of anesthetized rats was catheterized, and bile was collected. Bile volume and total bile acid production following intraperitoneal administration of folinic acid were determined and compared to those of control rats.
Both bile volume and total bile acid production increased following intraabdominal administration of folinic acid.
Folinic acid has a newly described pharmacologic effect of stimulating bile acid-dependent choleresis. It is possible that folinic acid may become a new drug for the treatment of jaundice or for the improvement of overall liver function.
背景/目的：在使用5-氟尿嘧啶和亚叶酸钙对复发性胃癌进行化疗时，观察到一种有趣的现象，即黄疸减轻和肝功能改善。本研究的目的是探讨这一现象的机制，并证实亚叶酸钙的利胆作用。
将麻醉大鼠的胆管插管，收集胆汁。测定腹腔注射亚叶酸钙后胆汁体积和总胆汁酸生成量，并与对照大鼠进行比较。
腹腔注射亚叶酸钙后，胆汁体积和总胆汁酸生成量均增加。
亚叶酸钙具有一种新描述的刺激胆汁酸依赖性胆汁分泌的药理作用。亚叶酸钙有可能成为治疗黄疸或改善整体肝功能的新药。
