Kroker R, Anwer M S, Hegner D
Acta Hepatogastroenterol (Stuttg). 1977 Oct;24(5):348-54.
The influence of the choleretic drug methylumbilliferone on bile formation in the isolated perfused rat liver is characterized. The compound induces rapidly an elevation of bile flow, bile acid secretion and soium excretion. The increased production of bile is of canalicular origin. The choleretic effect was defined as "bile acid like" choleresis due to excretion of the drug into the bile. It is discussed that the excretion of methylumbilliferone can influence the transport of bile in form of a positive cooperation on transport mechanism.
研究了利胆药物甲基伞形酮对离体灌注大鼠肝脏胆汁生成的影响。该化合物可迅速引起胆汁流量、胆汁酸分泌和钠排泄增加。胆汁生成增加源于胆小管。由于药物排泄到胆汁中，这种利胆作用被定义为“胆汁酸样”利胆作用。讨论了甲基伞形酮的排泄可能通过对转运机制的正协同作用影响胆汁的转运。
