Oishi M, Mochizuki Y
Department of Neurology, Nihon University, Nerima Hikarigaoka Hospital, Tokyo, Japan.
J Neurol. 1998 Dec;245(12):777-80. doi: 10.1007/s004150050286.
Cerebral blood flow and cerebrospinal fluid amino acids were investigated in patients with leukoaraiosis on magnetic resonance imaging. Ten patients with leukoaraiosis and without significant cerebral infarction and ten age-matched controls without abnormality on magnetic resonance imaging were studied. The regional cerebral blood flow was measured using the stable xenon computed tomography method. The blood flow was significantly lower in the leukoaraiosis area in the leukoaraiosis group than in the same area in the control group. The cerebrospinal fluid glutamate concentration was significantly higher in the leukoaraiosis group than in the control group. There was a significant negative correlation between the blood flow in the leukoaraiosis area and the cerebrospinal fluid glutamate concentration. The high concentration of cerebrospinal fluid glutamate in patients with leukoaraiosis is considered to be related to ischaemia.
对磁共振成像显示有脑白质疏松症的患者进行了脑血流量和脑脊液氨基酸的研究。研究了10例有脑白质疏松症且无明显脑梗死的患者以及10例磁共振成像无异常的年龄匹配对照者。使用稳定氙计算机断层扫描方法测量局部脑血流量。脑白质疏松症组脑白质疏松区域的血流量显著低于对照组的相同区域。脑白质疏松症组脑脊液谷氨酸浓度显著高于对照组。脑白质疏松区域的血流量与脑脊液谷氨酸浓度之间存在显著负相关。脑白质疏松症患者脑脊液谷氨酸浓度升高被认为与缺血有关。
