Knapen M F, Mulder T P, Van Rooij I A, Peters W H, Steegers E A
Department of Obstetrics and Gynecology, University Hospital St. Radboud, Nijmegen, The Netherlands.
Obstet Gynecol. 1998 Dec;92(6):1012-5. doi: 10.1016/s0029-7844(98)00333-0.
To investigate the pathophysiologic involvement of glutathione in pregnancies complicated by preeclampsia or the hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome.
Total whole blood glutathione levels were measured by high performance liquid chromatography in 23 women with pregnancies complicated by preeclampsia or the HELLP syndrome and in 22 normotensive gravidas. Total glutathione levels and the total glutathione/hemoglobin ratios of patients were compared with those of controls by the Mann-Whitney U test.
Median total glutathione levels were lower in preeclamptic pregnancies or those complicated by the HELLP syndrome than in normotensive pregnancies (647 [range 268-986] and 750 [range 495-1572] micromol/L, P = .05). The median total glutathione/hemoglobin ratios were significantly lower in preeclamptic pregnancies or in those complicated by the HELLP syndrome than in normotensive pregnancies (0.079 [range 0.033-0.122] and 0.101 [range 0.073-0.210], P = .02).
Decreased total glutathione levels in maternal whole blood might indicate decreased detoxificating or free radical scavenging capacity in pregnancies complicated by preeclampsia or the HELLP syndrome.
研究谷胱甘肽在子痫前期或溶血、肝酶升高、血小板减少（HELLP）综合征合并妊娠中的病理生理作用。
采用高效液相色谱法测定23例子痫前期或HELLP综合征合并妊娠妇女及22例血压正常孕妇的全血谷胱甘肽水平。采用Mann-Whitney U检验比较患者与对照组的总谷胱甘肽水平及总谷胱甘肽/血红蛋白比值。
子痫前期妊娠或合并HELLP综合征的妊娠中，总谷胱甘肽水平中位数低于血压正常的妊娠（分别为647[范围268 - 986]和750[范围495 - 1572]微摩尔/升，P = 0.05）。子痫前期妊娠或合并HELLP综合征的妊娠中，总谷胱甘肽/血红蛋白比值中位数显著低于血压正常的妊娠（分别为0.079[范围0.033 - 0.122]和0.101[范围0.073 - 0.210]，P = 0.02）。
孕产妇全血中总谷胱甘肽水平降低可能表明子痫前期或HELLP综合征合并妊娠时解毒或自由基清除能力下降。
