Robertson C H, Reynolds R C, Wilson J E
Am J Med. 1976 Nov;61(5):657-64. doi: 10.1016/0002-9343(76)90144-3.
In this report we confirm the presence of pulmonary hypertension by cardiac catheterization in four intravenous drug abusers with biopsy-documented foreign body granulomas in the pulmonary vessels and interstitium. Each patient had a history of intravenous injections of alpha-sympathomimetic agents obtained from nasal inhalers. There agents may have contributed to the disease by constricting small vessels when simultaneously injected foreign bodies were passing through the vasculature of the lung. The severity of the pulmonary hypertension correlated well with the decrease in single breath diffusing capacity in each case. Pulmonary hypertension may contribute significantly to the increased morbidity and mortality observed in intravenous drug users.
在本报告中，我们通过心脏导管插入术证实了4名静脉药物滥用者存在肺动脉高压，这些患者的肺血管和间质中有经活检证实的异物肉芽肿。每位患者都有从鼻吸入器获取的α-拟交感神经药静脉注射史。当同时注射的异物通过肺部血管系统时，这些药物可能通过收缩小血管而导致了该疾病。在每种情况下，肺动脉高压的严重程度与单次呼吸弥散能力的降低密切相关。肺动脉高压可能是导致静脉药物使用者发病率和死亡率增加的重要因素。
