Ballem P
Women's and Family Health, Children's and Women's Health Centre of British Columbia, and University of British Columbia, Vancouver, Canada.
Semin Thromb Hemost. 1998;24 Suppl 1:41-7.
Thromboembolic disease remains the most frequent cause of perinatal mortality in the Western world. Much has been written about the management of patients with underlying inherited thrombophilic disorders during pregnancy. However, a number of factors, such as age over 35 years, multiparity, and cesarean section are strong predictors of an increased risk of venous thrombosis and pulmonary embolus. Poorly controlled hypertension, especially in the setting of preeclampsia and eclampsia, is a risk factor for stroke. Appropriate preventive guidelines in these settings must be developed. In addition, various acquired preexisting conditions are associated with thromboembolic disease during pregnancy. In this article, the acquired syndromes of ovarian vein thrombosis, essential thrombocythemia, antiphospholipid syndrome, and cardiac valvular disease during pregnancy will be discussed, and the appropriate preventive and therapeutic interventions for these conditions will be reviewed. Proper management of acquired thrombophilia during pregnancy requires vigilance and a thorough understanding of the risks associated with the condition and its therapy.
在西方世界，血栓栓塞性疾病仍然是围产期死亡最常见的原因。关于患有潜在遗传性血栓形成倾向疾病的患者在孕期的管理，已有大量著述。然而，一些因素，如年龄超过35岁、多胎妊娠和剖宫产，是静脉血栓形成和肺栓塞风险增加的有力预测因素。控制不佳的高血压，尤其是在子痫前期和子痫的情况下，是中风的危险因素。必须制定这些情况下的适当预防指南。此外，各种获得性既往疾病与孕期血栓栓塞性疾病相关。在本文中，将讨论孕期卵巢静脉血栓形成、原发性血小板增多症、抗磷脂综合征和心脏瓣膜病的获得性综合征，并回顾针对这些情况的适当预防和治疗干预措施。孕期获得性血栓形成倾向的恰当管理需要警惕，并透彻了解与该病症及其治疗相关的风险。
