Shenouda A, Hatch F E
Am J Med. 1976 Nov;61(5):697-702. doi: 10.1016/0002-9343(76)90148-0.
The clinical and laboratory findings in four cases of acute renal failure following the onset of influenza A viral infection (Port Chalmers/1/73) are presented. Although the pathophysiologic mechanisms affecting the kidney in these cases varied, the ensuing renal failure in each patient was severe. Findings suggestive of acute myoglobinuria developed in one patient, and disseminated intravascular coagulation (DIC) occurred in another. The role of viruses in the pathogenesis of renal disease is reviewed. Despite inconclusive evidence that the influenza virus can cause human renal disease, the secondary pathways that can be triggered by viral infections may be even more significant in producing various degrees of renal dysfunction. The occurrence of renal failure during an episode of influenza represents a serious complication which may influence significantly the morbidity and mortality of patients with this viral infection.
本文报告了4例甲型流感病毒感染（查尔默斯港/1/73）后发生急性肾衰竭的临床和实验室检查结果。尽管这些病例中影响肾脏的病理生理机制各不相同，但每位患者随后出现的肾衰竭都很严重。1例患者出现提示急性肌红蛋白尿的表现，另1例发生了弥散性血管内凝血（DIC）。本文对病毒在肾脏疾病发病机制中的作用进行了综述。尽管尚无确凿证据表明流感病毒可导致人类肾脏疾病，但病毒感染引发的继发途径在导致不同程度的肾功能障碍方面可能更为重要。流感发作期间出现肾衰竭是一种严重的并发症，可能会显著影响该病毒感染患者的发病率和死亡率。
