Nakamura A, Tanaka S, Takayama H, Sakamoto M, Ishii H, Kusano M, Onizuka Y, Ota S, Mitamura K
Second Department of Internal Medicine, Showa University School of Medicine, Tokyo.
Intern Med. 1998 Oct;37(10):884-90. doi: 10.2169/internalmedicine.37.884.
A 77-year-old female was admitted to our hospital because of pyrexia and a right retroperitoneal mass. Leukocytosis and other inflammatory findings were noted. Bone-marrow aspiration revealed hypercellularity with no malignant cells. An additional mass was detected sonographically in the pelvis. The serum concentration of granulocyte colony-stimulating factor (G-CSF) was highly elevated (299 pg/ml). The tumors were removed at laparotomy, and the pelvic mass was found to arise from the ileocecal mesentery. Postoperatively, white blood cell count and serum G-CSF concentrations decreased to normal levels. The mesenteric tumor showed weakly positive immunostaining for human G-CSF, and Northern and polymerase chain reaction (PCR) analyses detected CSF and its mRNA in the mesenteric tumor.
一名77岁女性因发热和右腹膜后肿块入住我院。发现白细胞增多及其他炎症表现。骨髓穿刺显示细胞增多但无恶性细胞。超声检查在盆腔发现另一个肿块。粒细胞集落刺激因子（G-CSF）血清浓度显著升高（299 pg/ml）。在剖腹手术中切除肿瘤，发现盆腔肿块起源于回盲部肠系膜。术后，白细胞计数和血清G-CSF浓度降至正常水平。肠系膜肿瘤对人G-CSF免疫染色呈弱阳性，Northern和聚合酶链反应（PCR）分析在肠系膜肿瘤中检测到CSF及其mRNA。
