Departments of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan.
Int J Gynecol Pathol. 2012 Mar;31(2):172-177. doi: 10.1097/PGP.0b013e3182359f2f.
Uterine leiomyosarcoma associated with the paraneoplastic production of granulocyte-colony stimulating factor (GCSF) is extremely rare. No case has been reported to date in the English literature. We describe a case of a 56-year-old female with recurrent uterin leiomyosarcoma, associated with leukocytosis (19100/mm) and an elevated serum GCSF (33.0 pg/ml). Tumore histology was consistent with a well differentiated leiomyosarcoma with marked neutrophilic infiltration of the lung and spleen metastases. tumor cells were distinctly positive for GCSF on immunohistochemistry. These findings confirmed the diagnosis of a GCSF-producting uterine leiomyosarcoma with a paraneoplastic leukocytosis.
与副瘤性产生粒细胞集落刺激因子 (GCSF) 相关的子宫平滑肌肉瘤极为罕见。迄今为止，在英语文献中尚无报道。我们描述了一例 56 岁女性复发性子宫平滑肌肉瘤，伴有白细胞增多症（19100/mm）和血清 GCSF 升高（33.0 pg/ml）。肿瘤组织学表现为分化良好的平滑肌肉瘤，伴有肺和脾脏转移的明显中性粒细胞浸润。肿瘤细胞在免疫组织化学上明显呈 GCSF 阳性。这些发现证实了 GCSF 产生的子宫平滑肌肉瘤伴副瘤性白细胞增多症的诊断。
