骨髓受累与低度非霍奇金淋巴瘤的预后
Bone marrow involvement and the prognosis of low grade non-Hodgkin's lymphoma.
作者信息
Zemunik T, Vucković J, Marinković M, Forempoher G
机构信息
Department of Biology, Split University School of Medicine, Spinciceva 1, HR-21000 Split, Croatia.
出版信息
Croat Med J. 1998 Dec;39(4):419-21.
AIM
To analyze the bone marrow (BM) infiltration in low-grade non-Hodgkin's lymphomas (LGNHL) and assess its association with the histopathology type, clinical behavior, and disease prognosis.
METHOD
BM smears obtained by needle biopsy and stained by standard methods were analyzed in 60 patients with LGNHL using the Working Formulation.
RESULTS
BM infiltration was observed in 57% of the lymphocytic lymphomas (A), in 48% of lymphoplasmocytic/ plasmocytoid lymphomas (AI), and in 31% of follicular lymphomas (follicular small cleaved cell and follicular mixed B and C). The difference was not significant. The 5-year survival rates for patients with and without bone marrow infiltration were 53% and 56% respectively, and 10-year survival rates were 31% and 45% (p>0.05).
CONCLUSION
The presence of bone marrow infiltration at diagnosis did not significantly affect the prognosis of LGNHL.
目的
分析低度非霍奇金淋巴瘤（LGNHL）的骨髓浸润情况，并评估其与组织病理学类型、临床行为及疾病预后的相关性。
方法
采用工作分类法，对60例LGNHL患者经针吸活检获取的骨髓涂片进行标准方法染色并分析。
结果
在淋巴细胞性淋巴瘤（A）中，57%观察到骨髓浸润；在淋巴浆细胞性/浆细胞样淋巴瘤（AI）中，48%观察到骨髓浸润；在滤泡性淋巴瘤（滤泡性小裂细胞型以及滤泡性B和C混合型）中，31%观察到骨髓浸润。差异无统计学意义。有骨髓浸润和无骨髓浸润患者的5年生存率分别为53%和56%，10年生存率分别为31%和45%（p>0.05）。
结论
诊断时骨髓浸润的存在对LGNHL的预后无显著影响。
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