Hubbard R W, Matthew W T, Linduska J D, Curtis F C, Bowers W D, Leav I, Mager M
Am J Physiol. 1976 Oct;231(4):1119-23. doi: 10.1152/ajplegacy.1976.231.4.1119.
To assess the lethal effects of work-induced hyperthermia on exercising animals, untrained rats were run to exhaustion at 5 and 20-26 degrees C or restrained at 41.5 degrees C. An exercise-induced core temperature of 40.4 degrees C represented a base line above which mortalities occurred. With increasing core temperature at exhaustion (between 40.4 and 43 degrees C), mortality increased within 24 h. A dose-respones curve with an LD50 equivalent to a core temperature of 41.5 +/- 0.1 degrees C was calculated. Although differences in body weight loss, core temperature at exhaustion, and cooling rate will clearly distinguish between survivors and fatalities, the severity of heat injury as inferred from survival times is best measured by the time versus intensity of hyperthermia in degree-minutes.
为评估工作引起的体温过高对运动中动物的致死效应，将未经训练的大鼠在5℃和20 - 26℃下运动至力竭，或在41.5℃下进行束缚。运动引起的核心体温达到40.4℃代表一个基线，高于此温度即发生死亡。随着力竭时核心体温升高（在40.4℃至43℃之间），24小时内死亡率增加。计算得出一条半数致死剂量（LD50）曲线，其相当于核心体温41.5±0.1℃。尽管体重减轻、力竭时的核心体温和降温速率的差异能明显区分存活者和死亡者，但从存活时间推断的热损伤严重程度，最好通过热疗强度（以度 - 分钟计）与时间的关系来衡量。
