Armstrong L E, Hubbard R W, Szlyk P C, Sils I V, Kraemer W J
U.S. Army Research Institute of Environmental Medicine, Heat Research and Exercise Physiology Divisions, Natick, Massachusetts 01760-5007.
Aviat Space Environ Med. 1988 Mar;59(3):262-6.
A 32-year-old male (Mr. A.), monitored during an 8-d heat acclimation (HA) investigation, unexpectedly exhibited heat intolerance and heat exhaustion. Thirteen other males completed HA without indications of either heat intolerance or heat exhaustion. Because Mr. A. responded normally to HA on days 1-4, the intervention of an unknown host factor on days 5-8 was suggested. Mr. A.'s heat exhaustion episode (day 8) was apparently forewarned by loss of body weight and increased delta HR, delta Tsk (days 5-8) and delta Tre (days 7-8) during daily 90-min trials. His symptoms indicated classical salt depletion heat exhaustion, but the calculated salt deficit (less than 0.1 g NaCl.kg-1 body weight) was mild. Post-heat exhaustion serum enzyme levels were either normal (ALT, AST) or acutely elevated (CPK). Blood beta-endorphin and cortisol levels were six times and two times greater than control values, respectively. This case report is unique because clinical/physiological measurements and blood analyses were performed before, during, and after heat intolerance and heat exhaustion.
一名32岁男性（A先生）在为期8天的热适应（HA）调查监测期间，意外出现耐热性差和热衰竭症状。其他13名男性完成了热适应，未出现耐热性差或热衰竭迹象。由于A先生在第1 - 4天对热适应反应正常，因此推测在第5 - 8天有未知宿主因素介入。在每天90分钟的试验期间，A先生体重减轻以及ΔHR、ΔTsk（第5 - 8天）和ΔTre（第7 - 8天）增加，显然预示着他在第8天会出现热衰竭。他的症状表明为典型的缺盐性热衰竭，但计算出的缺盐量（低于0.1 g NaCl·kg⁻¹体重）较轻。热衰竭后血清酶水平要么正常（ALT、AST），要么急剧升高（CPK）。血液β - 内啡肽和皮质醇水平分别比对照值高6倍和2倍。该病例报告具有独特性，因为在耐热性差和热衰竭之前、期间及之后都进行了临床/生理测量和血液分析。
