Hubbard R W, Matthew W T, Criss R E, Kelly C, Sils I, Mager M, Bowers W D, Wolfe D
J Appl Physiol Respir Environ Exerc Physiol. 1978 Sep;45(3):463-8. doi: 10.1152/jappl.1978.45.3.463.
A total of 171 untrained, unacclimatized, and unanesthetized rats were used to evaluate the effects of sedentary and work-induced hyperthermia on the incidence of mortality and cellular injury, 24 h postexposure. Cellular injury was defined as serum transaminase activity (SGPT and SGOT) exceeding 1,000 IU/l (heatstroke levels). Both the percent mortality and the percentage of 24-h survivors with transaminase levels above 1,000 IU/l were plotted against maximum core temperatures. Exertion-induced hyperthermia produced a significantly higher incidence of cellular injury and heatstroke death at lower core temperatures than hyperthermia alone. With hyperthermia only, the SGPT and SGOT dose-response curves were identical. When work was combined with hyperthermia, there was a greater incidence of elevated SGOT at lower core temperatures. These curves bore a striking resemblance to curves reflecting heat- and/or work-induced mortality in humans. The results suggest a direct role of physical effort in causing heatstroke injury and mortality.
总共171只未经训练、未适应环境且未麻醉的大鼠被用于评估久坐和工作诱导的体温过高对暴露后24小时死亡率和细胞损伤发生率的影响。细胞损伤定义为血清转氨酶活性（SGPT和SGOT）超过1000 IU/l（中暑水平）。将死亡率百分比和转氨酶水平高于1000 IU/l的24小时存活者百分比与最高核心温度进行绘图。与单纯体温过高相比，运动诱导的体温过高在较低核心温度下导致细胞损伤和中暑死亡的发生率显著更高。仅体温过高时，SGPT和SGOT剂量反应曲线相同。当工作与体温过高相结合时，在较低核心温度下SGOT升高的发生率更高。这些曲线与反映人类热和/或工作诱导死亡率的曲线极为相似。结果表明体力活动在导致中暑损伤和死亡中起直接作用。
