Tenderini M L, Ravagnan P, Galliani E A, Faggian D, Plebani M, Acerbi E, Martini G, De Lazzari F
Servizio di Immunoematologia, Azienda Ospedaliera, Padova.
Minerva Pediatr. 1998 May;50(5):157-61.
Cord blood IgE levels have been studied as a possible marker of allergy in infants but few studies are available in our Region. The aim of this paper was to test IgE levels in cord blood of 60 consecutive newborns in a restricted area of Veneto, to correlate cord blood IgE levels with family history of allergy and to verify the risk of contamination from mother's blood.
Cord blood was obtained from 60 consecutive newborns. Immunoglobulin levels (IgG, IgA, IgM, and IgE) were measured in cord blood of newborns and in serum of all mothers. Family history for allergy was previously investigated from the mothers.
IgE were detectable in cord blood of 5 newborns but only 2 of them had positive family history for allergy which was pointed out in 11/60. In one of these cases the contamination of sample from mother's blood was postulated. IgG levels in newborn cord blood were higher than in mothers' blood and it was not related with IgE levels or other investigated factors.
Only 6.6% of newborns in a restricted area of Veneto region have detectable IgE in cord blood whereas 18.3% of them have positive family history for allergy. Measurable levels of IgE in cord blood are not related with positive family history of allergy and are rarely influenced by mothers' blood contamination.
脐血IgE水平已被作为婴儿过敏的一种可能标志物进行研究，但在我们这个地区相关研究较少。本文的目的是检测威尼托一个特定区域内60例连续新生儿的脐血IgE水平，将脐血IgE水平与过敏家族史相关联，并验证母亲血液污染的风险。
采集60例连续新生儿的脐血。检测新生儿脐血及所有母亲血清中的免疫球蛋白水平（IgG、IgA、IgM和IgE）。此前已对母亲进行过敏家族史调查。
5例新生儿的脐血中可检测到IgE，但其中只有2例有过敏家族史，60例中有11例有过敏家族史。在其中1例中推测样本受到母亲血液污染。新生儿脐血中的IgG水平高于母亲血液中的IgG水平，且与IgE水平或其他调查因素无关。
在威尼托地区一个特定区域内，只有6.6%的新生儿脐血中可检测到IgE，而其中18.3%有过敏家族史。脐血中可测量的IgE水平与过敏家族史阳性无关，且很少受母亲血液污染的影响。
