Iikura Y, Akimoto K, Odajima Y, Akazawa A, Nagakura T
Department of Allergy and Clinical Immunology, National Children's Medical Research Center, Tokyo, Japan.
Int Arch Allergy Appl Immunol. 1989;88(1-2):250-2.
We have investigated methods for decreasing the number of allergic patients and have produced the following data. We compared mothers' total IgE levels and allergen-specific IgG and IgG4 levels in 72 paired cases. In mothers with high total IgE, the cord blood levels of IgG and IgG4 specific for egg, milk, and mite allergens were significantly higher than in mothers with low IgE levels. Mothers who took over 200 ml of milk per day showed a statistically higher level of milk-specific IgG antibody. From our studies of IgE, IgG, and IgG4 antibody levels in atopic dermatitis patients, we conclude that specific IgG and IgG4 levels should be considered when eliminating offending foods. Infants with high egg-specific IgG antibody levels in cord blood were statistically more prone to develop allergic disease.
我们研究了减少过敏患者数量的方法，并得出了以下数据。我们比较了72对母婴的母亲总IgE水平以及过敏原特异性IgG和IgG4水平。在总IgE水平高的母亲中，针对鸡蛋、牛奶和螨虫过敏原的脐带血IgG和IgG4水平显著高于总IgE水平低的母亲。每天摄入超过200毫升牛奶的母亲，其牛奶特异性IgG抗体水平在统计学上更高。通过对特应性皮炎患者IgE、IgG和IgG4抗体水平的研究，我们得出结论，在排除引起过敏的食物时应考虑特异性IgG和IgG4水平。脐带血中鸡蛋特异性IgG抗体水平高的婴儿在统计学上更易患过敏性疾病。
