Pérez Rodríguez A, Isla García A, Fernández I, Más Lago P, García Rodríguez A I, Rodríguez Concepción A
Instituto de Medicina Tropical Pedro Kourí.
Rev Cubana Med Trop. 1998;50(1):54-60.
Of the 115 patients who suffered from epidemic neuropathy and received attention from March 16 de April 30, 1993, at the Center for Medical and Surgical Research (CMSR), in Havana City, 114 controls were selected at random in the community. In the univariate analysis it was found a significant association mainly with the smoking habit (odds ratio = 3.45 [95% confidence interval 1.85 to 6.35)] and with the consumption of edible fat of uncertified procedence (odds ratio = 2.77 [95% confidence interval 1.34 to 5.8]). All were ratified in the multivariate logistical regression analysis. Association (odds ratio = 8.8 [95% confidence interval 2.58 to 30.55] with the presence of antibodies against the Coxsackie virus A-9 strain 47 was also found among the 182 individuals who had serological test. It seems that the toxic factor derived from the smoking habit, together with the deficiency of some nutrients due to the changes occurred in the diet, as well as the contact with the isolated virus in one of the patients facilitated the clinical expression of this disease and therefore in the origin of the epidemics.
1993年3月16日至4月30日期间，在哈瓦那市医学与外科研究中心（CMSR）接受关注的115例流行性神经病患者中，从社区中随机选取了114名对照。单因素分析发现，主要与吸烟习惯（比值比=3.45[95%置信区间1.85至6.35]）以及食用未经认证来源的食用脂肪（比值比=2.77[95%置信区间1.34至5.8]）存在显著关联。所有这些在多因素逻辑回归分析中都得到了验证。在182名进行了血清学检测的个体中，还发现与抗柯萨奇病毒A-9株47抗体的存在存在关联（比值比=8.8[95%置信区间2.58至30.55]）。似乎吸烟习惯产生的毒性因素，加上饮食变化导致的某些营养素缺乏，以及其中一名患者与分离出的病毒接触，促成了这种疾病的临床表现，进而导致了疫情的爆发。
