Appel P W, Gordon N B
Am J Psychiatry. 1976 Nov;133(11):1337-40. doi: 10.1176/ajp.133.11.1337.
The digit-symbol substituion task (DSST) of the WAIS was given to working (MW) and nonworking (MNW) patients on high-dose methadone maintenance and to two comparison groups to assess the function of attention in these patients. Mean DSST scores were significantly lower for the MNW group than for the other three groups, which did not differ. However, the scores for the MNW group were within the normal range. DSST scores and lenght of methadon treatment (range: 11 months to 8 years) were positively correlated, providing no evidence of deterioration with increasing duration of treatment.
对接受大剂量美沙酮维持治疗的在职患者(MW)和非在职患者(MNW)以及两个对照组进行了韦氏成人智力量表(WAIS)的数字符号替换测验(DSST),以评估这些患者的注意力功能。MNW组的DSST平均得分显著低于其他三组,而其他三组之间没有差异。然而,MNW组的得分仍在正常范围内。DSST得分与美沙酮治疗时长(范围:11个月至8年)呈正相关,这表明没有证据显示随着治疗时间延长功能会恶化。