Sheard M H, Marini J L, Bridges C I, Wagner E
Am J Psychiatry. 1976 Dec;133(12):1409-13. doi: 10.1176/ajp.133.12.1409.
The authors conducted a double-blind, placebo-controlled study of the effect of lithium on aggressive behavior. The 66 subjects, who were prisoners in a medium security institution, ranged in age from 16 to 24 years, were physically healthy and nonpsychotic, and had histories of chronic impulsive aggressive behavior. Subjects received lithium or placebo daily for up to 3 months. There was a significant reduction in aggressive behavior in the lithium group as measured by a decrease in infractions involving violence. The authors suggest that lithium can have a clinically useful effect upon impulsive aggressive behavior when this behavior is not associated with psychosis.
作者进行了一项关于锂对攻击行为影响的双盲、安慰剂对照研究。66名受试者是一所中等安全级别的机构中的囚犯，年龄在16至24岁之间，身体健康且无精神病，并有慢性冲动攻击行为史。受试者每天接受锂或安慰剂治疗，最长可达3个月。通过涉及暴力的违规行为减少来衡量，锂组的攻击行为有显著减少。作者认为，当冲动攻击行为与精神病无关时，锂对其可能具有临床有用的效果。
