Marini J L, Sheard M H
Acta Psychiatr Scand. 1977 Apr;55(4):269-86. doi: 10.1111/j.1600-0447.1977.tb00172.x.
In studies of the psychopharmacology of human aggression, 'aggression' should be related to easily identifiable behavior: angry threats or actual assaults. Aspects of behavior not meeting these criteria but relevant to a study of aggression should be described using appropriate terms such as social dominance, initiative, etc. With these conventions, examination of the heterogeneous literature on lithium treatment of aggression demonstrates that lithium ion exerts an antiaggressive effect in man. A number of hypotheses for the antiaggressive effect are examined using previous studies and new behavioral and biochemical data. It is concluded that the anti-aggressive effect is not due to any of the following: lithium toxicity or side effects; subjective or objective weakness; increased reaction time; reduced coordination or motor performance; frank cognitive deficits; hypothyroidism; reduction of serum testosterone; placebo effect; or underlying manic-depressive illness. Putative "thymoleptic" properties of lithium are too ambiguous to constitute an explanation of lithium's actions in man.
在人类攻击行为的精神药理学研究中，“攻击行为”应与易于识别的行为相关：愤怒威胁或实际攻击。不符合这些标准但与攻击行为研究相关的行为方面，应使用适当的术语进行描述，如社会主导性、主动性等。根据这些惯例，对关于锂治疗攻击行为的异质性文献进行考察表明，锂离子在人类中具有抗攻击作用。利用先前的研究以及新的行为和生化数据，对一些关于抗攻击作用的假说进行了考察。得出的结论是，抗攻击作用并非由以下任何一种原因引起：锂毒性或副作用；主观或客观虚弱；反应时间增加；协调性或运动表现降低；明显的认知缺陷；甲状腺功能减退；血清睾酮降低；安慰剂效应；或潜在的躁狂抑郁症。锂假定的“心境稳定剂”特性过于模糊，不足以解释锂在人类中的作用。
