Fujii Y, Saitoh Y, Tanaka H, Toyooka H
Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan.
Anesth Analg. 1998 Dec;87(6):1404-7. doi: 10.1097/00000539-199812000-00037.
In this prospective, randomized, double-blinded study, we evaluated the efficacy of the oral antiemetics, granisetron and domperidone, for the prevention of postoperative nausea and vomiting (PONV) in 100 women undergoing major gynecologic surgery. Patients received either granisetron 2 mg or domperidone 20 mg (n = 50 in each group) orally 1 h before surgery. Standardized anesthetic techniques and postoperative analgesia regimens were used. Complete response (defined as no PONV and no administration of rescue antiemetic medication) for 0-3 h after anesthesia was 88% with granisetron and 52% with domperidone; the corresponding incidence for 3-24 h after anesthesia was 86% and 48% (P < 0.05). No clinically important adverse events due to the drugs were observed in any of the groups. In conclusion, the efficacy of preoperative oral granisetron is superior to that of domperidone for the prevention of PONV after major gynecologic surgery.
We compared the efficacy of granisetron and domperidone administered orally for the prevention of postoperative nausea and vomiting in women undergoing gynecologic surgery. Preoperative oral granisetron was more effective than domperidone.
在这项前瞻性、随机、双盲研究中，我们评估了口服止吐药格拉司琼和多潘立酮对100例接受大型妇科手术的女性预防术后恶心和呕吐（PONV）的疗效。患者在手术前1小时口服2毫克格拉司琼或20毫克多潘立酮（每组n = 50）。采用标准化的麻醉技术和术后镇痛方案。麻醉后0 - 3小时的完全缓解率（定义为无PONV且未使用急救止吐药物），格拉司琼组为88%，多潘立酮组为52%；麻醉后3 - 24小时的相应发生率分别为86%和48%（P < 0.05）。在任何一组中均未观察到因药物引起具有临床意义的不良事件。总之，术前口服格拉司琼预防大型妇科手术后PONV的疗效优于多潘立酮。
我们比较了口服格拉司琼和多潘立酮预防妇科手术女性术后恶心和呕吐的疗效。术前口服格拉司琼比多潘立酮更有效。
