Failure of sorivudine therapy in progressive outer retinal necrosis caused by varicella zoster virus.
作者信息
Rosenthal G, Bartz-Schmidt K U, Walter P, Kirchhof B, Heimann K
机构信息
Department of Vitreoretinal Surgery, University of Cologne, Germany.
出版信息
Aust N Z J Ophthalmol. 1998 Nov;26(4):327-8. doi: 10.1111/j.1442-9071.1998.tb01337.x.
BACKGROUND
We report on the case of a 23-year-old female who presented with ocular signs of progressive outer retinal necrosis (PORN) syndrome and who failed to respond to acyclovir, ganciclovir, foscarnet and oral sorivudine.
METHODS
The patient was treated with the antiviral drugs acyclovir, ganciclovir, foscarnet and oral sorivudine.
RESULTS
The patient failed to respond to a combination of antiviral drugs. Unfortunately, progression of the retintis occurred, which led to blindness.
CONCLUSION
Despite new drugs, the prognosis of PORN is poor and recurrence is common.
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