Nos P, Garrigues V, Caballero E, Cano M C, Sopena R, Ponce J
Servicio de Medicina Digestiva, Hospital La Fe, Valencia.
Gastroenterol Hepatol. 1998 Oct;21(8):386-90.
The evaluation of gastric emptying by the double isotope technique involves some methodologic conditioning. Among them contamination correction or interference in the energy windows of the activity of the two isotopes used in the marking of the solids and fluids of the test food are important. The results of an experiment in which a phantom was used to evaluate the contamination between indio 111 (DTPA-Ca111In) and technecium 99m (colloid99mTc). Three test studies were posteriorly performed in healthy volunteers and 27 studies in a control group (13 males, mean age of 33 years, mean body mass index 39.02 kg/m). In these studies the contamination was corrected with the acquisition, following an initial swallow of juice marked with 111In, of activity in the windows of both isotopes. The contamination of 111In (isotope of greatest radiation energy) in the window of 99mTc was 24% in the phantom and 20%, 23% and 26% in the three initial study tests. The mean contamination in the control group was of 22% with limits of 19% to 29% and a standard deviation of 3%. Despite the comparable results, the usefulness of the individualized contamination calculation in the studies of gastric emptying with dual isotope to minimize the methodologic errors of this technique is discussed.
采用双同位素技术评估胃排空涉及一些方法学条件。其中，用于标记测试食物固体和液体的两种同位素活度的能量窗中的污染校正或干扰很重要。一项实验的结果，该实验使用体模评估铟 - 111（二乙三胺五乙酸钙 - 铟 - 111，DTPA - Ca111In）和锝 - 99m（胶体99mTc）之间的污染。随后在健康志愿者中进行了三项测试研究，在一个对照组中进行了27项研究（13名男性，平均年龄33岁，平均体重指数39.02kg/m）。在这些研究中，在最初吞咽标记有111In的果汁后，通过采集两种同位素窗中的活度来校正污染。在体模中，99mTc窗中111In（辐射能量最大的同位素）的污染为24%，在三项初始测试研究中分别为20%、23%和26%。对照组中的平均污染为22%，范围为19%至29%，标准差为3%。尽管结果具有可比性，但仍讨论了在双同位素胃排空研究中进行个体化污染计算以尽量减少该技术方法学误差的实用性。
