Mazzoccoli G, Bianco G, Correra M, Carella A M, Balzanelli M, Giuliani A, Tarquini R
Dipartimento di Medicina Interna, IRCCS Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Foggia.
Recenti Prog Med. 1998 Nov;89(11):569-72.
In our study cortisol and interleukin 2 (IL-2) levels were measured and lymphocyte sub-population analyses were performed on blood samples collected every four hours, for 24 hours from 10 healthy subjects aged 38-65 years. A clear circadian rhythm was validated for cortisol serum levels, for CD8, CD8 dim, CD16 and delta TcS1 with acrophase in the morning, and for CD2, CD4, CD/CD8 ratio, HLA-DR, CD20 and CD25 with acrophase at night. CD8 bright and TcR delta 1 presented higher levels in the morning without validation of the circadian rhythm. Changes of serum levels of IL-2 did not show circadian rhythmicity. The results show that specific lymphocyte subsets present different profiles of nyctohemeral changes and this may explain time related variations of immune responses.
在我们的研究中，对10名年龄在38 - 65岁的健康受试者每隔4小时采集一次血样，共采集24小时，测量其皮质醇和白细胞介素2（IL - 2）水平，并进行淋巴细胞亚群分析。验证了皮质醇血清水平、CD8、CD8 dim、CD16和δTcS1的明显昼夜节律，其高峰相位在早晨；以及CD2、CD4、CD/CD8比值、HLA - DR、CD20和CD25的明显昼夜节律，其高峰相位在夜间。CD8 bright和TcRδ1在早晨呈现较高水平，但未验证其昼夜节律。IL - 2血清水平的变化未显示昼夜节律性。结果表明，特定的淋巴细胞亚群呈现出不同的昼夜变化模式，这可能解释了免疫反应的时间相关变化。
