Buijs P C, Krabbe-Hartkamp M J, Bakker C J, de Lange E E, Ramos L M, Breteler M M, Mali W P
Department of Radiology, University Hospital Utrecht, Heidelberglaan, The Netherlands.
Radiology. 1998 Dec;209(3):667-74. doi: 10.1148/radiology.209.3.9844657.
To determine the normal values and effects of age and sex on total cerebral blood flow (CBF) as measured with ungated two-dimensional phase-contrast magnetic resonance (MR) angiography.
Volume flow rates in the basilar artery and both internal carotid arteries were measured on two-dimensional phase-contrast MR angiograms obtained in 250 subjects (age range, 19-88 years; mean age, 50 years) undergoing MR imaging because of indications other than cerebrovascular disease. Volume flow rates for the three arteries were summed to obtain the total CBF, and the values were analyzed in terms of age and sex.
Mean total CBF was 616 mL/min +/- 143. There was a significant yearly decrease with age in total CBF of 4.8 mL/min (P < .001). Mean total CBF ranged from 748 mL/min +/- 121 to 474 mL/min +/- 105 in subjects aged 19-29 and 80-89 years, respectively. No sex differences were found. Mean relative contributions of the right and left internal carotid arteries and the basilar artery to total CBF were 41%, 40%, and 19%, respectively, with no substantial change due to age.
Ungated two-dimensional phase-contrast MR angiography is a useful, noninvasive technique for assessing total CBF. By using this technique, a significant decrease in total CBF with age was demonstrated.
通过非门控二维相位对比磁共振血管造影术，确定全脑血流量（CBF）的正常值以及年龄和性别对其的影响。
在250名因非脑血管疾病适应症接受磁共振成像检查的受试者（年龄范围19 - 88岁；平均年龄50岁）所获得的二维相位对比磁共振血管造影图上，测量基底动脉和双侧颈内动脉的血流量。将三条动脉的血流量相加得出全脑血流量，并根据年龄和性别对这些值进行分析。
平均全脑血流量为616 mL/min ± 143。全脑血流量随年龄增长每年显著下降4.8 mL/min（P < 0.001）。19 - 29岁和80 - 89岁受试者的平均全脑血流量分别为748 mL/min ± 121和474 mL/min ± 105。未发现性别差异。右侧和左侧颈内动脉以及基底动脉对全脑血流量的平均相对贡献分别为41%、40%和19%，且未因年龄而发生实质性变化。
非门控二维相位对比磁共振血管造影术是评估全脑血流量的一种有用的非侵入性技术。通过使用该技术，证明了全脑血流量随年龄显著下降。
