Párraga H C, Párraga M I, Spinner L R, Kelly D P, Morgan S L
Fourth Street Clinic, Springfield, Illinois, USA.
Int J Psychiatry Med. 1998;28(3):341-51. doi: 10.2190/R91L-YAR6-QFH2-X56P.
As many as 35 percent of Tourette's Syndrome patients do not acquire this disorder genetically. Since there has been little research conducted in this area, the purpose of this study was to compare the clinical differences between two groups of patients with Tourette's Syndrome (TS), one with family history of TS and one without.
Using data of eight previously diagnosed TS patients, the authors made comparisons of clinical and sociodemographic variables between a group of three patients with family history of TS and five with no family history.
There were no differences in clinical presentation, current age, age at diagnosis, gender, and socioeconomic status. There were differences in birth history, developmental milestones, I.Q., and neurological findings between patients with family history and no family history of TS.
Our findings support the need for testing the hypothesis of a multidetermined origin of TS, a disorder in which hereditary, neuropsychological, and environmental factors play a role.
多达35%的妥瑞氏综合征患者并非遗传获得该疾病。由于该领域的研究较少，本研究的目的是比较两组妥瑞氏综合征（TS）患者的临床差异，一组有TS家族史，另一组没有。
作者利用8例先前诊断为TS患者的数据，对一组3例有TS家族史的患者和5例无家族史的患者的临床及社会人口统计学变量进行了比较。
临床表现、当前年龄、诊断年龄、性别和社会经济地位方面没有差异。有TS家族史和无家族史的患者在出生史、发育里程碑、智商和神经学检查结果方面存在差异。
我们的研究结果支持对TS多因素起源假说进行检验的必要性，TS是一种遗传、神经心理和环境因素都起作用的疾病。
