Tel'kina G N, Sorkin V M
Lik Sprava. 1998 Aug(6):143-5.
A method is proposed for calculation of PMSO frequency depending on succession of origination of polyneoplasias. The incidence rate of synchronous bilateral breast cancer (BC) was calculated in reference to all primary BC patients and came to 0.75%. The incidence rate of metachronous bilateral BC was calculated depending on the number of those BC patients having been registered every year of observation and it was found to be 5.4%. The total frequency of bilateral BC in a 20-year follow-up in the Crimean region appeared to be 6.15%. The incidence of metachronous bilateral BC was noted to be dependent on the length of follow-up: 1.27 percent and 4.14 percent in the 3- to 10- and 11- to 20-year periods respectively. The risk for the development of bilateral BC is conditioned by the time having elapsed since detection of the first tumor and increases after 10 and 18 years.
提出了一种根据多原发癌发生顺序计算双侧原发性乳腺癌（PMSO）频率的方法。参照所有原发性乳腺癌患者计算了同步双侧乳腺癌（BC）的发病率，结果为0.75%。根据观察每年登记的乳腺癌患者数量计算了异时双侧乳腺癌的发病率，发现为5.4%。在克里米亚地区进行的20年随访中，双侧乳腺癌的总发生率为6.15%。注意到异时双侧乳腺癌的发病率取决于随访时间：在3至10年和11至20年期间分别为1.27%和4.14%。双侧乳腺癌发生的风险取决于自首次发现肿瘤以来所经过的时间，并在10年和18年后增加。
