Tüzün A, Aydin A, Turan M
GATA Dept. of Gastroenterology, Ankara, Turkey.
Biol Trace Elem Res. 1998 Summer;64(1-3):169-74. doi: 10.1007/BF02783333.
Selenium (Se), zinc (Zn), copper (Cu), and antioxidant enzyme (superoxide dismutase [SOD] and glutathione peroxidase [GSH-Px]) levels in sera were detected in Behçet patients. Age and sex matched controls were used to find out if oxidative stress takes place in the etiopathogenesis of Behçet's disease. Superoxide dismutase levels were found to be lower in the whole patients group when compared to controls. In whole patients and inactive patients' group Zn and Se levels were found to be higher, but not different in the active patients group when compared to controls. No significant difference was found between the groups as Cu and glutathione peroxidase levels were taken into consideration. According to the results of the present study, SOD level is low in Behçet's disease patients' sera independent from the phase of the disease, and as a result of decreased SOD activity, increased production of free oxygen radicals may play a role in the etiopathogenesis of the disease.
检测了白塞病患者血清中的硒（Se）、锌（Zn）、铜（Cu）以及抗氧化酶（超氧化物歧化酶[SOD]和谷胱甘肽过氧化物酶[GSH-Px]）水平。采用年龄和性别匹配的对照组来探究氧化应激是否在白塞病的病因发病机制中发生。与对照组相比，整个患者组的超氧化物歧化酶水平较低。在整个患者组和非活动期患者组中，锌和硒水平较高，但与对照组相比，活动期患者组无差异。考虑铜和谷胱甘肽过氧化物酶水平时，各组之间未发现显著差异。根据本研究结果，白塞病患者血清中的超氧化物歧化酶水平较低，且与疾病阶段无关，由于超氧化物歧化酶活性降低，游离氧自由基产生增加可能在该病的病因发病机制中起作用。
