Normal canine lipid profiles and effects of experimentally induced pancreatitis and hepatic necrosis on lipids.

Normal lipid profiles (total lipids, total cholesterol, phospholipids, free fatty acids, triglycerides, and lipoproteins) were determined in 23 clinic-reared dogs and 26 client-owned dogs. A significantly higher concentration of cholesterol was found in client-owned dogs as compared with clinic-reared dogs. Hepatic necorosis, induced by CCl4, resulted only in a significant decrease in triglycerides. Acute pancreatitis, induced by major and minor pancreatic duct ligations, resulted in a significant increase in free fatty acids and low-density lipoprotein with a decrease in high-density lipoprotein-2.