[Relationship between genotype of angiotensin converting enzyme gene and left ventricular hypertrophy in Chinese hypertensives].

OBJECTIVE

To search into the relationship between genotype of angiotensin-converting enzyme (ACE) gene and left ventricular hypertrophy(LVH) in Chinese hypertensives.

METHODS

ACE genotyping with polymerase chain reaction (PCR) was performed in 33 unrelated hypertensives with LVH, 55 hypertensives without cardio-cerebrovascular diseases and 62 healthy controls.

RESULTS

The frequencies of DD genotype (0.394) and deletion allele (0.606) among hypertensives with LVH were significantly higher than those (0.129 and 0.387) among controls and those (0.128 and 0.400) among hypertensives without cardio-cerebrovascular diseases.

CONCLUSION

A deletion polymorphism of ACE gene probably increases the risk for left ventricular hypertrophy in Chinese hypertensives.