[中国高血压患者血管紧张素转换酶基因多态性与脑梗死的关系]

[The relationship between angiotensin-converting enzyme gene polymorphism and brain infarction in Chinese hypertensives].

作者信息

Shen D, Ha D

机构信息

Department of Gerontology, Second Affiliated Hospital, Hubei Medical University, Wuhan, Hubei Province, 430071 P.R.China.

出版信息

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1998 Jun 10;15(3):136-8.

PMID:9621118

Abstract

OBJECTIVE

To identify the insertion/deletion(I/D) polymorphism of angiotensin-converting enzyme(ACE) gene in Chinese hypertensives complicated with brain infarction.

METHODS

ACE genotyping with polymerase chain reaction(PCR) was performed in 62 unrelated healthy controls, 55 hypertensives without cardio-cerebrovascular diseases and 44 hypertensives complicated with brain infarction (all controls had no hypertension family history, while the cases had hypertension family history).

RESULTS

No significant differences could be detected between ACE gene I/D polymorphism and hypertension. However,the frequencies of DD genotype and deletion allele among hypertensives complicated with brain infarction (29.6% vs 56.8%) were higher than those among healthy controls (12.9% vs 38.7%, P<0.05 and P<0.01) and those among hypertensive without cardio-cerebrovascular diseases(12. 8% vs 40%, P<0.05 and P<0.02).

CONCLUSION

A deletion polymorphism of ACE gene is probably an important hereditary factor of brain infarction's morbidity in Chinese hypertensives. The detection of ACE genotypes in hypertensives would improve the early diagnosis of brain infarction.

摘要

目的

鉴定中国高血压合并脑梗死患者血管紧张素转换酶（ACE）基因的插入/缺失（I/D）多态性。

方法

采用聚合酶链反应（PCR）对62名无亲缘关系的健康对照者、55名无心血管脑血管疾病的高血压患者和44名高血压合并脑梗死患者进行ACE基因分型（所有对照者无高血压家族史，而病例有高血压家族史）。

结果

ACE基因I/D多态性与高血压之间未检测到显著差异。然而，高血压合并脑梗死患者中DD基因型和缺失等位基因的频率（分别为29.6%和56.8%）高于健康对照者（分别为12.9%和38.7%，P<0.05和P<0.01）以及无心血管脑血管疾病的高血压患者（分别为12.8%和40%，P<0.05和P<0.02）。