Love R G, Muir D C
Am Rev Respir Dis. 1976 Nov;114(5):891-7. doi: 10.1164/arrd.1976.114.5.891.
Intrapulmonary deposition of 1-mum-diameter particles of dioctyl sebacate was studied in 58 working coalminers. Total deposition was found to be significantly correlated with lung function measurements characterizing airway obstruction. The closest relationship was between deposition and the mean maximal flow rate in the third quarter of a forced expiration. The shape of the exhaled aerosol recovery curve was also found to be related to the degree of airway obstruction; 3 basic types are described. The concave type was more common in smokers, in whom deposition was significantly greater. The presence of simple pneumoconiosis was not associated with the degree of aerosol deposition. The significance of the findings of aerosol deposition and its recovery pattern are discussed in relation to the pathogenesis of lung disease.
对58名在职煤矿工人进行了癸二酸二辛酯1微米直径颗粒的肺内沉积研究。发现总沉积量与表征气道阻塞的肺功能测量值显著相关。最密切的关系存在于沉积量与用力呼气第三季度的平均最大流速之间。还发现呼出气雾剂回收曲线的形状与气道阻塞程度有关；描述了3种基本类型。凹形在吸烟者中更常见，他们的沉积量明显更大。单纯尘肺的存在与气雾剂沉积程度无关。结合肺部疾病的发病机制讨论了气雾剂沉积及其回收模式研究结果的意义。
