Pavia D, Thomson M L, Clarke S W, Shannon H S
Thorax. 1977 Apr;32(2):194-7. doi: 10.1136/thx.32.2.194.
The method using radioactive tracer particles has been applied to study the effect of the mode of inhalation of aerosols on the depth of deposition in the lungs of 50 patients with airways obstruction. The findings show that the penetration of particles is directly related to: (1) volume inspired per breath (VI); (2) forced expiratory volume in one second (FEV1); and inversely related to (3) flow rate during inhalation (V). In mathematical terms, alveolar deposition (%) = 40-3 (VI)+10-98 (FEV1)--0-75 (V)+40-4; for this regression F = 4-41 and P less than 0-01.
采用放射性示踪颗粒的方法已被用于研究气溶胶吸入方式对50例气道阻塞患者肺部沉积深度的影响。研究结果表明，颗粒的穿透与以下因素直接相关：（1）每次呼吸吸入的气量（VI）；（2）一秒用力呼气量（FEV1）；与以下因素呈负相关：（3）吸气时的流速（V）。用数学术语表示，肺泡沉积率（%）=40 - 3（VI）+10 - 98（FEV1）- 0 - 75（V）+40 - 4；对于该回归方程，F = 4 - 41，P＜0 - 01。
