Evlakhov V I, Shalkovskaia L N
Institute of Experimental Medicine of the Russian Acad. Med. Sci., St. Petersburg, Russia.
Ross Fiziol Zh Im I M Sechenova. 1998 Sep;84(9):845-52.
In anesthetised cats, i.v. administration of epinephrine (EP) in combination with acetylcholine (ACH) caused a decline of arterial pressure (AP), cardiac output (CO) and heart rate (HR) whereas stroke volume (SV) and total peripheral resistance (TPR) were increased. Combined administration of the HIS (histamine) and EP caused a decrease in only the AP and TPR, whereas CO, HR and SV were increased. The findings suggest that changes of systemic haemodynamics following combined i.v. administration of humoral stimuli depend on the mechanism of their action on the heart and vessels.
在麻醉猫中，静脉注射肾上腺素（EP）与乙酰胆碱（ACH）联合使用会导致动脉压（AP）、心输出量（CO）和心率（HR）下降，而每搏输出量（SV）和总外周阻力（TPR）增加。组胺（HIS）与EP联合给药仅导致AP和TPR下降，而CO、HR和SV增加。这些发现表明，静脉联合注射体液刺激物后全身血液动力学的变化取决于它们对心脏和血管的作用机制。
