Lioznov M V, Tkachenko B I
Fiziol Zh SSSR Im I M Sechenova. 1991 Apr;77(4):24-33.
The direction and obviousness of changes in systemic arterial and venous vascular beds occurring in combined action of two similarly acting pressor and depressor vasoactive drugs, were studied in acute experiments in cats. The changes of last and general peripheral resistance of vessels were greater under the action of the two drugs as compared to the effect of a single drug, and yet less obvious than their algebraic sum. The shifts in cardiac output and venous return were not greater than the most obvious response to a single drug. The same was true for the blood flow changes in v. v. cavae. Irrespective of the mechanism of action of vasoactive drugs and the direction of shifts of systemic AP, single and combined drugs increased the blood flow in the v. cava anterior whereas the v. cava posterior's blood flow changed in different directions.
在猫的急性实验中，研究了两种作用相似的升压和降压血管活性药物联合作用时，全身动脉和静脉血管床变化的方向和明显程度。与单一药物的作用相比，两种药物联合作用下血管的终末和总外周阻力变化更大，但比它们的代数和要小。心输出量和静脉回流量的变化不大于对单一药物最明显的反应。腔静脉的血流变化情况也是如此。无论血管活性药物的作用机制和全身动脉血压变化的方向如何，单一药物和联合药物均增加了前腔静脉的血流量，而后腔静脉的血流量则朝不同方向变化。
