Gilinskiĭ M A, Kolosova N G, Petrakova G M
Vestn Ross Akad Med Nauk. 1998(10):22-6.
The adaptive characteristics of the body, including the specific features of increased cold resistance upon repeated exposures to cold, are determined not only by the properties of thermogenic structures themselves, but largely depend on the contribution of the central mechanisms which control the processes of habituation and mobilization of functions. The experiments revealed an increase in cold resistance in rats after preexposure to cold. Immobilization stress prior to training cold significantly decreased rapid cold resistance in the animals, but increased the training effect of the first cooling. On the contrary, chlordiazepoxide increased cold resistance during the first cooling. Testing of the untreated animal showed no effect of training. No adaptive changes in cold resistance occurred in rats with impaired amygdaloid complex. Analyzing adrenal catecholamines revealed a significant elevation of dopamine concentrations in the rats exposed to cold. Hypothalamic catecholamines did not change with cold and serotonin in intact rats and 5-hydroxyindoleacetic acid in amygdalectomized rats substantially increased.
机体的适应性特征，包括反复接触寒冷后耐寒性增强的具体特征，不仅取决于产热结构本身的特性，还在很大程度上取决于控制习惯化过程和功能动员的中枢机制的作用。实验表明，大鼠预先暴露于寒冷环境后耐寒性增强。在训练耐寒前施加固定应激显著降低了动物的快速耐寒性，但增强了首次降温的训练效果。相反，氯氮卓在首次降温期间增强了耐寒性。对未处理动物的测试表明训练无效。杏仁复合体受损的大鼠未出现耐寒性的适应性变化。分析肾上腺儿茶酚胺发现，暴露于寒冷环境的大鼠多巴胺浓度显著升高。完整大鼠的下丘脑儿茶酚胺在寒冷时未发生变化，杏仁核切除大鼠的血清素和5-羟吲哚乙酸显著增加。
