Carlos A G, Carlos M L, Santos M A, Pedro E, Santos S, Lopes-Pregal A
Clinica Universitaria de Medicina I, Instituto de Imunologia e Centro de Hematologia e Imunologia, Faculdade de Medicina de Lisboa, Portugal.
Allerg Immunol (Paris). 1998 Oct;30(8):257-8.
Tryptase is the more specific markers for mast cell activation and mediators release and can be used as an index of mast cell activation after challenge. Nasal provocation tests have been done in patients allergic to the pollen of Parietaria (pellitory wall) before and after specific systemic immunotherapy and tryptase release evaluated in nasal lavage fluid. After specific immunotherapy the concentration of tryptase in nasal lavage was significantly decreased to all the concentrations used in challenge and the peack of tryptase release was delayed. These results confirm that assays of tryptase in nasal fluid after nasal provocation are a reliable markers of mast cell activation. Immunotherapy with specific allergen decreases mast cell reactivity to the same allergen.
类胰蛋白酶是肥大细胞活化和介质释放更具特异性的标志物，可作为激发后肥大细胞活化的指标。已对花粉过敏的患者在特异性全身免疫治疗前后进行了针对墙草花粉的鼻激发试验，并对鼻灌洗液中的类胰蛋白酶释放情况进行了评估。特异性免疫治疗后，鼻灌洗液中类胰蛋白酶的浓度在激发试验所用的所有浓度下均显著降低，且类胰蛋白酶释放的峰值延迟出现。这些结果证实，鼻激发试验后鼻液中类胰蛋白酶的检测是肥大细胞活化的可靠标志物。特异性变应原免疫治疗可降低肥大细胞对同一变应原的反应性。
