间质性肺疾病患者支气管肺泡灌洗中的T淋巴细胞活化

T lymphocyte activation in bronchoalveolar lavage of patients with interstitial lung disease.

作者信息

Harmancy E, Gülbas Z, Ozdemir N, Elbek O, Mutlu S, Kolsuz M, Yurdasiper A

机构信息

Department of Chest Diseases and Haematology, Osmangazi University, Medical Faculty, Eskisehir, Turkey.

出版信息

Allerg Immunol (Paris). 1998 Oct;30(8):259-61.

PMID:9846196

Abstract

To study the role of T-lymphocytes in the patients with alveolitis due to interstitial lung disease (ILD), we have examined T cell populations in bronchoalveolar lavage (BAL) and peripheral blood (PB) of ten patients with ILD and six normal-controls via flow cytometry. The percentages of T-lymphocytes bearing the activation markers of HLA-DR (p < 0.01) and CD25 (p < 0.05) were significantly higher in BAL of ILD patients. There was no correlation between T lymphocytes subtypes and pulmonary functions and diffusion capacity (p > 0.05). In PB of ILD patients had less CD4+ T lymphocytes and CD19 cells (B lymphocytes) than controls (p < 0.05). This increased T-lymphocyte activation in BAL in contrast to PB suggested to have a role in the pathogenesis of the lung involvement in ILD.

摘要

为研究T淋巴细胞在间质性肺疾病（ILD）所致肺泡炎患者中的作用，我们通过流式细胞术检测了10例ILD患者及6例正常对照者的支气管肺泡灌洗（BAL）液和外周血（PB）中的T细胞亚群。ILD患者BAL液中携带HLA-DR激活标志物（p<0.01）和CD25（p<0.05）的T淋巴细胞百分比显著更高。T淋巴细胞亚群与肺功能及弥散能力之间无相关性（p>0.05）。与对照组相比，ILD患者PB中的CD4+T淋巴细胞和CD19细胞（B淋巴细胞）较少（p<0.05）。与PB相比，BAL中T淋巴细胞激活增加提示其在ILD肺部受累的发病机制中起作用。