Domoua K, N'Dhatz M, Coulibaly G, Traore F, Koffi J, Achi V, Daix T, Ouattara Y, Ouedraogo M, Beugre L K, Konan J B, Coulibaly V, Coulibaly I M, Yapi A
Service de pneumo-phtisiologie, CHU de Treichville, Abidjan, Côte d'Ivoire.
Bull Soc Pathol Exot. 1998;91(4):312-4.
From December 1992 to February 1993, 104 newly diagnosed pulmonary tuberculosis patients were enrolled in a prospective cohort study to assess the response to the 6 month-short-course regimen implemented in Cote d'Ivoire. This treatment encompassed the daily intake of Rifampicin and Pyrazinamide for 2 months followed by Rifampicin and Isoniazid for the remaining 4 months. All the patients were enrolled at the Treichville Tuberculosis Treatment Centre in Abidjan, and a follow-up of 6 months was observed for each patient. All in all, 41 patients were HIV-positive whereas 63 where HIV-negative. No statistical difference was noted between HIV-positive and HIV-negative patients with regard to the completion of therapy (85% versus 87%). The cure rate after an effective 6 month-therapy was similar among HIV-positive and HIV-negative patients (83% versus 84%) as well as the treatment failure rate which was 2.4% and 3% respectively. The results clearly indicate that the 6 month-short-course regimen policy implemented in Côte d'Ivoire is as effective for the treatment of HIV-associated tuberculosis as for the treatment of tuberculosis.
1992年12月至1993年2月，104名新诊断的肺结核患者被纳入一项前瞻性队列研究，以评估对科特迪瓦实施的6个月短程治疗方案的反应。该治疗包括每日服用利福平及吡嗪酰胺2个月，随后服用利福平和异烟肼4个月。所有患者均在阿比让的特雷什维尔结核病治疗中心登记，并对每位患者进行了6个月的随访。总共有41名患者HIV呈阳性，63名患者HIV呈阴性。在治疗完成方面，HIV阳性和HIV阴性患者之间未发现统计学差异（85%对87%）。在接受6个月有效治疗后，HIV阳性和HIV阴性患者的治愈率相似（83%对84%），治疗失败率分别为2.4%和3%。结果清楚地表明，科特迪瓦实施的6个月短程治疗方案政策在治疗HIV相关结核病和结核病方面同样有效。
