Nuñez J L, Juraska J M
Neuroscience Program, University of Illinois at Champaign-Urbana 61820, USA.
Dev Psychobiol. 1998 Dec;33(4):295-303. doi: 10.1002/(sici)1098-2302(199812)33:4<295::aid-dev1>3.0.co;2-l.
The splenium (posterior 1/5) of the corpus callosum is sexually dimorphic in the adult rat brain. In the present study we examined the role of developmental hormones and cryoanesthesia (which is normally used during the performance of neonatal hormone manipulations) on the gross size of the splenium in male and female rats. There was a sex difference in splenial size (male > female) among nonhormonally manipulated animals, p = .0007. While neonatal castration was ineffective in altering the size of the male splenium, testosterone injections in females were found to increase the size of the splenium relative to oil-injected females, p = .05. The effect of developmental testosterone was further observed: Sex ratio (males to females) of the litter correlated with splenial area in females, r = .55, p = .03. Duration of cryoanesthesia negatively correlated with splenial area in males, r = -.81, p = .03, with a similar trend in females.
成年大鼠脑中胼胝体压部（后五分之一部分）存在性别差异。在本研究中，我们研究了发育激素和冷冻麻醉（通常在新生动物激素处理过程中使用）对雄性和雌性大鼠胼胝体压部总体大小的作用。在未进行激素处理的动物中，胼胝体压部大小存在性别差异（雄性>雌性），p = 0.0007。虽然新生期去势对改变雄性胼胝体压部大小无效，但发现给雌性注射睾酮会使其胼胝体压部大小相对于注射油的雌性有所增加，p = 0.05。进一步观察到发育过程中睾酮的作用：窝仔的性别比例（雄性与雌性）与雌性胼胝体压部面积相关，r = 0.55，p = 0.03。冷冻麻醉持续时间与雄性胼胝体压部面积呈负相关，r = -0.81，p = 0.03，雌性也有类似趋势。
