Rottem S, Naot Y
Dept of Membrane and Ultrastructure Research, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Trends Microbiol. 1998 Nov;6(11):436-40. doi: 10.1016/s0966-842x(98)01358-4.
Mycoplasmas are minute wall-less bacterial parasites that exhibit strict host and tissue specificities. They enter, multiply and survive within the host for extended periods by circumventing host defenses. Their intimate interaction with eukaryotic cells, and in some cases the subsequent invasion into or fusion with these cells, mediates cell damage. Mycoplasmas also modulate the activity of host cells by a variety of direct mechanisms and/or indirectly by cytokine-mediated effects.
支原体是微小的无壁细菌寄生虫，具有严格的宿主和组织特异性。它们通过规避宿主防御机制，在宿主体内长时间侵入、繁殖并存活。它们与真核细胞的密切相互作用，以及在某些情况下随后侵入这些细胞或与这些细胞融合，介导细胞损伤。支原体还通过多种直接机制和/或间接通过细胞因子介导的效应来调节宿主细胞的活性。
