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Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration.

作者信息

Nagahara H, Vocero-Akbani A M, Snyder E L, Ho A, Latham D G, Lissy N A, Becker-Hapak M, Ezhevsky S A, Dowdy S F

机构信息

Howard Hughes Medical Institute, Dept of Pathology and Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

出版信息

Nat Med. 1998 Dec;4(12):1449-52. doi: 10.1038/4042.

DOI:10.1038/4042
PMID:9846587
Abstract
摘要

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Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration.全长TAT融合蛋白导入哺乳动物细胞:TAT-p27Kip1诱导细胞迁移。
Nat Med. 1998 Dec;4(12):1449-52. doi: 10.1038/4042.
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Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1.白细胞介素-6和制瘤素M诱导的人A375黑色素瘤细胞生长抑制是依赖信号转导和转录激活因子(STAT)的,并且涉及细胞周期蛋白依赖性激酶抑制剂p27/Kip1的上调。
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