解析 SAMHD1 在子宫内膜癌进展中的作用。
Deciphering the role of SAMHD1 in endometrial cancer progression.
机构信息
Department of Obstetrics and Gynecology, The First People's Hospital of Zhangjiagang City, The Zhangjiagang Affiliated Hospital of Soochow University, Suzhou, 215600, China.
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, No. 1055, Sanxiang Road, Suzhou, Jiangsu Province, 215000, China.
出版信息
Biol Direct. 2024 Oct 11;19(1):89. doi: 10.1186/s13062-024-00525-7.
BACKGROUND
Endometrial cancer (EC) presents significant clinical challenges due to its heterogeneity and complex pathophysiology. SAMHD1, known for its role as a deoxynucleotide triphosphate triphosphohydrolase, has been implicated in the progression of various cancers, including EC. This study focuses on elucidating the role of SAMHD1 in EC through its impact on TRIM27-mediated PTEN ubiquitination.
RESULTS
Utilizing a combination of bioinformatics and cellular biology techniques, we investigated the interactions among SAMHD1, TRIM27, and PTEN. Our findings reveal that SAMHD1 modulates PTEN ubiquitination via TRIM27, impacting key pathways involved in EC pathogenesis. These interactions suggest a critical mechanism by which SAMHD1 could influence tumor behavior and progression in EC.
CONCLUSIONS
The results from this study underscore the potential of targeting the SAMHD1-TRIM27-PTEN axis as a therapeutic strategy in EC. By providing new insights into the molecular mechanisms underlying EC progression, our research supports the development of novel therapeutic approaches that could contribute to improve treatment strategies for patients with EC.
背景
子宫内膜癌（EC）因其异质性和复杂的病理生理学而带来重大的临床挑战。SAMHD1 作为一种脱氧核苷酸三磷酸三磷酸水解酶而闻名，其与包括 EC 在内的各种癌症的进展有关。本研究通过研究 SAMHD1 对 TRIM27 介导的 PTEN 泛素化的影响，旨在阐明 SAMHD1 在 EC 中的作用。
结果
我们利用生物信息学和细胞生物学技术的组合，研究了 SAMHD1、TRIM27 和 PTEN 之间的相互作用。我们的发现表明，SAMHD1 通过 TRIM27 调节 PTEN 的泛素化，影响 EC 发病机制中涉及的关键途径。这些相互作用表明，SAMHD1 可能通过影响 EC 中的肿瘤行为和进展来影响肿瘤行为和进展的关键机制。
结论
本研究的结果强调了将 SAMHD1-TRIM27-PTEN 轴作为 EC 的治疗策略的潜力。通过为 EC 进展的分子机制提供新的见解，我们的研究支持开发新的治疗方法的研究，这可能有助于改善 EC 患者的治疗策略。
Zotero 插件