Ogawa T, Ohira A, Amemiya T
Department of Ophthalmology, Nagasaki University School of Medicine, Sakamoto, Japan.
Curr Eye Res. 1998 Nov;17(11):1067-73. doi: 10.1076/ceyr.17.11.1067.5231.
To examine the relationship between retinal degeneration and superoxide dismutase (SOD) in the degenerative retina of the WBN/Kob rat.
The retinas of 4-week-old and 10-month-old WBN/ Kob rats were examined with immunohistochemistry and immunoblotting. Wistar Kyoto rats were used as controls.
Retinal degeneration began 4 weeks after birth. Four-week-old WBN/Kob rats showed no manganese superoxide dismutase (Mn-SOD) immunoreactivity in the photoreceptor inner segments or copper-zinc superoxide dismutase (CuZn-SOD) immunoreactivity in the outer nuclear layer or photoreceptor inner segments. Control 4-week-old Wistar Kyoto rats showed positive immunoreactivities at these sites.
The retinal degeneration of WBN/Kob rats begins in the outer retina. The lack of SODs in the outer retina may contribute to retinal degeneration in the WBN/Kob rats.
研究WBN/Kob大鼠退化视网膜中视网膜变性与超氧化物歧化酶（SOD）之间的关系。
采用免疫组织化学和免疫印迹法检测4周龄和10月龄WBN/Kob大鼠的视网膜。以Wistar Kyoto大鼠作为对照。
视网膜变性在出生后4周开始。4周龄的WBN/Kob大鼠在光感受器内节未显示锰超氧化物歧化酶（Mn-SOD）免疫反应性，在外核层或光感受器内节未显示铜锌超氧化物歧化酶（CuZn-SOD）免疫反应性。对照4周龄Wistar Kyoto大鼠在这些部位显示阳性免疫反应性。
WBN/Kob大鼠的视网膜变性始于视网膜外层。视网膜外层缺乏超氧化物歧化酶可能导致WBN/Kob大鼠的视网膜变性。
