Mattsson P, Morgan B P, Svensson M
Karolinska Hospital, Department of Clinical Neuroscience, Stockholm, Sweden.
J Neuroimmunol. 1998 Nov 2;91(1-2):180-9. doi: 10.1016/s0165-5728(98)00178-7.
Intracranial transection of the facial nerve has been shown to cause a massive neuronal cell death in the motor facial nucleus. Complement activation has been proposed to contribute to neuronal degeneration following axotomy. Using immunocytochemistry and in situ hybridization we show in the present study that there is complement activation in the facial nucleus after intracranial facial nerve transection as well as increase of the complement regulators CD59 and clusterin. We propose a neuroprotective role for the complement regulators CD59 and clusterin against homologous attack of complement to facial motor neurons.
面神经的颅内横断已被证明会导致面神经运动核中大量神经元细胞死亡。有人提出补体激活促成了轴突切断术后的神经元变性。在本研究中，我们运用免疫细胞化学和原位杂交技术显示，颅内面神经横断后面神经核中有补体激活现象，同时补体调节蛋白CD59和聚集素也有所增加。我们提出补体调节蛋白CD59和聚集素对面部运动神经元具有抗补体同源攻击的神经保护作用。
