Maas M I, Hopman W P, Katan M B, Jansen J B
Department of Gastroenterology and Hepatology, University Hospital Nijmegen, The Netherlands.
Am J Clin Nutr. 1998 Dec;68(6):1272-5. doi: 10.1093/ajcn/68.6.1272.
We determined the effect of oral ingestion of sucrose polyester, which was approved as a fat replacer in the United States, on gallbladder motility and on the release of cholecystokinin, the hormone that mediates gallbladder emptying.
Our objective was to measure effects of sucrose polyester on gallbladder emptying and cholecystokinin release.
Eight healthy volunteers (3 men and 5 women) drank 60 mL sucrose polyester, digestible fat, or saline solution in a balanced crossover design on 3 separate days.
Mean (+/-SEM) gallbladder emptying, when integrated over time, was low in response to both sucrose polyester (-150 +/- 214 mL x 120 min) and saline solution (-89 +/- 123 mL x 120 min). In contrast, there was marked emptying in response to digestible fat (1069 +/- 253 mL x 120 min). Sucrose polyester did not affect plasma cholecystokinin concentrations (-9.3 +/- 15.0 pmol x 120 min/L), whereas digestible fat resulted in a significant increase (89.5 +/- 44.8 pmol x 120 min/L, P = 0.014) compared with saline solution (-3.0 +/- 13.8 pmol x 120 min/L).
Ingestion of sucrose polyester, in contrast with digestible fat, did not stimulate gallbladder emptying or release of cholecystokinin.
我们确定了口服蔗糖聚酯（在美国被批准作为脂肪替代品）对胆囊运动以及对胆囊收缩素释放的影响，胆囊收缩素是介导胆囊排空的激素。
我们的目的是测量蔗糖聚酯对胆囊排空和胆囊收缩素释放的影响。
八名健康志愿者（3名男性和5名女性）在3个不同的日子里，按照平衡交叉设计饮用60毫升蔗糖聚酯、可消化脂肪或盐溶液。
随着时间的推移，蔗糖聚酯（-150±214毫升×120分钟）和盐溶液（-89±123毫升×120分钟）引起的平均（±标准误）胆囊排空较低。相比之下，可消化脂肪引起了明显的排空（1069±253毫升×120分钟）。蔗糖聚酯不影响血浆胆囊收缩素浓度（-9.3±15.0皮摩尔×120分钟/升），而与盐溶液（-3.0±13.8皮摩尔×120分钟/升）相比，可消化脂肪导致其显著增加（89.5±44.8皮摩尔×120分钟/升，P = 0.014）。
与可消化脂肪相比，摄入蔗糖聚酯不会刺激胆囊排空或胆囊收缩素的释放。
